In conclusion the results obtained show that that piper betle l. Inhibitory action of piper betle on the initiation of 7,12dimethylbenzaanthraceneinduced mammary carcinogenesis in rats. Phytochemical studies show that piper betle contains a wide variety of biologically active compounds whose concentration. Isolation of these compounds from this source is being reported here. Leaves of fertile branches with a petiole 12cm long, 1. The test substances in this study were betel leaf infusion and povidoneiodine solution. Chavica betle an important species of the piperaceae family, is a climber that grows in india, indonesia, malaysia, the philippines, sri lanka, vietnam, and china with glossy heartshaped leaves that are magnificent reservoirs of phenolic compounds with antiproliferative, antimutagenic, antibacterial and antioxidant properties. Antioxidant, analgesic and antiinflammatory activities of. Das3 1institute of advanced study in science and technology, guwahati781 035, assam, india 2department of zoology, gauhati university, guwahati 781 014, assam. It is concluded that stems of piper betle linn is potent anthelmintic. Piper betle linn betle leaves have been folklore used as an ingredient of drugs for cutaneous wound treatment. Piperaceae is a common plant cultivated in asian countries. Pbl is the leaf of betel vine popularly known as paan and betel in english. Piper betle leaves are commonly referred to as green gold.
Piper betle linn is a wellknown and widely growing plant in south east asia, and it has. The phytochemistry, traditional uses and pharmacology of. The betel piper betle is a vine of the family piperaceae, which includes pepper and kava. Influence of phytochemicals in piper betle linn leaf extract on wound. Chavica betle an important species of the piperaceae family, is a climber that grows in india, indonesia, malaysia, the philippines, sri lanka, vietnam, and china with glossy heartshaped leaves that are magnificent reservoirs of phenolic compounds with antiproliferative, antimutagenic, antibacterial and antioxidant properties phytochemical studies show that. Linn, commonly known as betel vine, has been used as a religious, recreational and medicinal plant in southeast asia. The free radical scavenging action of piper betle could indicate the peptic ulcers are healing action through the antioxidative mechanism. Extracts of piper betle are used for the treatment of various ailments since ages due to its essential properties like antioxidant, anticancer, antiallergic etc. Ikmo piper betle, betel leaf pepper philippine medicinal. Conclusion in summary, taking all these data together, it. We have recently reported the antifilarial and antileishmanial efficacy in the leaf extract of bangla mahoba landrace of p. The plant is originated from india, philippines, bangladesh and sri lanka. Pretreatment of an ethanolic extract of leaf ofpiper betle linn at a dose of 200mgkg body weight, orally administered to rats for ten consecutive days, was found to possess a significant protective action against gastric lesions induced by indomethacin. The present study has revealed that ethyl acetate extract of piper betle showed prominent super oxide anion free radical scavenging activity and marked antioxidant defense.
Mediates its anti inflammatory activity via downregulation of nitric oxide. This study was carried out to investigate the hepatoprotective and antioxidant properties of p. In this study, piper betle linn leaf was extracted by using different solvents such as pe, chcl 3. Antibacterial effects of green betel piper betle linn. Antioxidant, analgesic and antiinflammatory activities of piper betle ajp, vol.
Streptococcus viridans, staphylococcus aureus and streptococcus mutans. Heartshaped piper betel leaves are magnificent reservoirs of phenolic compounds with antiproliferative, antimutagenic, antibacterial, and antioxidant properties. Healing impairment is caused by many reasons including increasing of free radicalsmediated damage, delaying in granulation tissue formation. Phytochemistry, pharmacological profile and therapeutic uses of piper betle linn. It is a vedic plant used in various traditional system of medicine v. A free radical that has sufficient energy to abstract an allylic hydrogen from the methylene carbon of. Original article application of piper betle as an antioxidant. Out of these, about 30 species have been reported in india. Column chromatography of the alcoholic extract of piper betle roots furnished aristololactam aii and a new phenyl propene, characterized as 4allyl resorcinol, while the petroleumether extract yielded a diketosteroid, viz. Basavaiah chandu, sharmila nurbasha, hari babu bollikolla. Betel leaves have a strong pungent flavor and is widely used as a masticatory. It is carminative, stimulant, astringent and is effective against parasitic worms. Phytochemistry, pharmacological profile and therapeutic. The extract pretreatment resulted in significant increase in superoxide dismutase sod and.
Dpph radical scavenging activity, superoxide radical scavenging activity in a riboflavinlightnbt system, hydroxyl radical scavenging activity and inhibition of lipid. These facts consequently lead to chronic wound healing. In vitro anthelmintic activity of stem extracts of piper. Antimicrobial property of piper betel leaf against. Antioxidant and antimicrobial potential of selected varieties of piper betle l. Chavica betle an important species of the piperaceae family, is a climber that grows in india, indonesia, malaysia, the philippines, sri lanka, vietnam, and china with glossy heartshaped leaves that are magnificent reservoirs of phenolic compounds with. It is cultivated in india, srilanka, malay, peninsula, philippine islands and east africa. Known as paan belongs to the plant family piperaceae. A facile green reduction for graphenesilver nanocomposite using betel leaf extract for the photocatalytic degradation of water pollutants. It has reported that piper betle linn extract showed antidiabetic and antiinflammatory effects showed antipyretic effect, leaves extracts showed antioxidant effect. Sudipto ganguly, soumyaditya mula, subrata chattopadhyay and mitali chatterjee 2007. Pdf many of the health benefits bonded with piper betel locally known as paan belongs to the piperaceae or.
Influence of phytochemicals in piper betle linn leaf extract. Widely consumed in south asian countries, the glossy leaf contains a multitude of biophenolics such. Satish a bhalerao 1, deepa r verma 2, rohan v gavankar 2, nikhil c teli 2, yatin y rane 3, vinodkumar s didwana 2 and ashwin trikannad 2. Introduction piper betle linn piperaceae is a perennial dioecious, semiwoody climber. Piperaceae is commonly known as green gold of india due to its high commercial value. Betel leaf is mostly consumed in asia, and elsewhere in the world by some asian emigrants, as betel quid or in paan, with areca nut andor tobacco. Piper betle dentifrice streptococcus mutans introduction piper betle linn leaves have long been used in indonesia as traditional medicine. Known as paan belongs to the plant family piperaceae 12. It belongs to the family of piperaceae growing to a height of 150 to 180 cm.
The betel leaf, which stimulates the nervous system, is chewed by people living in tropical asia. Piper betle synonyms, piper betle pronunciation, piper betle translation, english dictionary definition of piper betle. Stems strongly swollen at the nodes, papillose when young. Hypoglycemic and hypolipidemic properties of hydroxychavicol.
I t belongs to the dicotyledonous piperaceae family7. Antibacterial activity of betle leaf piper betle l. The ethanolic extract of stems of piper betle linn not only demonstrated anthelmintic property but they also caused death of the worms when compared with marketed standard preparation i. The present study investigates on the free radical scavenging. Traditionally betel leaf is chewing after taking meal having significant medicinal properties and nutritional values. Potent antiulcerogenic activity of ethanol extract of leaf of. Gcms analysis and antibacterial activity of piper betle linn leaves against streptococcus mutans. All these compounds were characterized by spectroscopic means. Phytochemical studies show that piper betle contains a wide variety of biologically active compounds whose.
It contains some vitamins, minerals and produce enzyme that helps in digestion and work as mouth freshener. The antiadherence effect of piper betle and psidium guajava extracts on the adhesion of early settlers in dental plaque to salivacoated glass surfaces. Antinociception, opioid receptor, piper betle leaves. Betel leaf article about betel leaf by the free dictionary. Pdf the heart shaped betel leaves are found in ancient sanskrit texts, including charaka. Effect of ethanol extract of piper betle linn leaf on. The aim of this study was to evaluate the antioxidant potential and possible applications of p. Effect of ethanol extract of piper betle linn leaf on healing. Piper betle pb is a traditional medicine that is widely used to treat different diseases around asian region. Leaves alternate, simple, and yellowish green to brightgreen in color. Universa medicina effectiveness of piper betle leaf.
Ayurveda system of medicine, yunani system of medicine attributed to various pharmacological activities v. Piperaceae is a widely distributed plant in the tropical and subtropical regions of the world and has been attributed as traditional herbal remedy for many diseases. In the present study, antioxidant activities of aqueous extracts of three local varieties of p. Past, present, and future since time immemorial, piper betle linn. Piperaceae is a perennial dioecious creeper, probably native of malaysia but cultivated in india for its leaves, used for chewing. The leaf extracts contain various bioactive compounds, which were reported to have antidiabetic, antibacterial, antiinflammatory, antioxidant, and anticancer effects. Isolation of these compounds from this source is being reported here for the first. Piper betle leaves are used as masticatory in asian countries. This plant is economically, ethnobotanically, ethnomedicinally and traditionally important in the whole world.
In this study, we aimed to investigate the healing efficacy of methanol leaf extract of piper betle linn on proliferation of fibroblast nih3t3 cells as. In this study, the effect of pb aqueous extracts on replicative senescent human diploid fibroblasts hdfs was. Ethanoltreated rats exhibited elevation of hepatic marker enzymes and disturbances in antioxidant defense when compared with normal rats. The extract pretreatment resulted in significant increase in superoxide dismutase sod and catalase cat activity, increase in mucus. Influence of piper betle on hepatic marker enzymes and. Influence of phytochemicals in piper betle linn leaf. Piper betle linn leaf is a wellknown plant in ancient medical sciences.
Gcms analysis and antibacterial activity of piper betlelinn leaves against streptococcus mutans. Purification of hydroxychavicol from piper betle linn and. Piper betle linn, is a handsome evergreen and perennial creeper, with glossy heartshaped leaves commonly known as the betel leaf. Piper betle linn, phytochemical, betle quid, pharmacological profile. However, the effect of betle leaf on wound healing is not yet well elucidated. The leaves, which are the most commonly used plant part, are pungent with aromatic flavor and are widely consumed as a mouth freshener.
Although it has many medicinal properties, such as stimulative, carminative, aphrodisiac. Potent antiulcerogenic activity of ethanol extract of leaf. These leaves have antimicrobial activity towards bacteria in the mouth i. Though the plant is known for abuse, in recent years several reports have been published on the effects of the. The heart shaped of piper betle leaves are initiate in ancient sanskrit texts, include charaka, sushruta samhita and astanga hradayam. Albendazole 40 mgml and different concentrations of aqueous extract. The nhexane and chloroform fractions of piper betle l.
Kumar et al5 have discussed in detail the pharmacological activities of p. Leaf against streptococcus agalactiae and escherichia coli this study investigated the effect of betel piper betle l. The extract pretreatment resulted in significant increase in superoxide dismutase sod and catalase cat activity, increase in. Plants contain a much greater diversity of bioactive compounds than any manmade chemical library. The most likely place of origin of betle vine is malaysia but it is also cultivated in india, srilanka, bangladesh, burma and nepal.
Evaluation of cytotoxic activity of piper betle linn. Ikmo, piper betle, betel leaf pepper herbal medicine an illustrated compilation of philippine medicinal plants by dr godofredo umali stuart, including botanical information, chemical properties, folkloric uses and reserach studies. Antinociceptive activities of aqueous and ethanol extracts. Antioxidant activity of piper betel leaf extract and its. Piper betle definition of piper betle by the free dictionary. Horadugoda gamage sujatha pushpakanthi hewageegana et al. Review study on potential activity of piper betle abstract piper betle is glorified as evergreen and perennial plant that god designed and have given the shape of his own heart. The genus piper contains above 700 species of plants and is spread in both hemispheres. Evaluation of antidermatophytic activity of piper betle, allamanda catherticaand their combination. Piper betle and gastric ulcer 17458 int j clin exp med 2016. The reversible antifertility effect of piper betle linn. Antinociceptive activities of aqueous and ethanol extracts of.